Responses of Plasma Acetate Metabolism to Hop (Humulus lupulus L.) in Sheep
An isotope dilution method using [1-13C]sodium (Na) acetate was conducted to determine the effect of feeding hop (Humulus lupulus L.) residues on plasma acetate metabolism in six adult crossbred...
View ArticleCharacterization of persistent TTX-R Na+ currents in physiological...
Persistent tetrodotoxin-resistant (TTX-R) Na+ (Nav1.9/SCN11A) currents are not normally recorded in vagal afferent neurons (VANs) with 50 mM of extracellular Na+ although the functional expression of...
View ArticleOld can be new again: HAPPY whole genome sequencing, mapping and assembly
During the last three decades, both genome mapping and sequencing methods have advanced significantly to provide a foundation for scientists to understand genome structures and functions in many...
View ArticleVesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by...
We investigated the potential usefulness of vesnarinone, a novel cytokine inhibitor, for the treatment of lung fibrosis using a murine model of bleomycin (BLM)-induced pulmonary fibrosis. Mice were...
View ArticleBody fat mass reduction and up-regulation of uncoupling protein by novel...
We have found natural products exhibiting lipolysis-promoting activity in subcutaneous adipocytes, which are less sensitive to hormones than visceral adipocytes. The activities and a action mechanisms...
View ArticleA male-specific odorant receptor conserved through the evolution of sex...
In many moths, mate-finding communication is mediated by the female sex pheromones. Since differentiation of sex pheromones is often associated with speciation, it is intriguing to know how the...
View ArticleIdentification of candidate genes for congenital splay leg in piglets by...
The congenital splay leg syndrome in piglets is characterized by a temporarily impaired functionality of the hind leg muscles immediately after birth. Etiology and pathogenetic mechanisms for the...
View ArticleModulation of NKT cells and Th1/Th2 imbalance after α-GalCer treatment in...
Purpose: The purpose of this study was to determine whether α-galactosylceramide (α-GalCer), a synthetic glycolipid agonist of natural killer T (NKT) cells, can ameliorate exercise-induced immune...
View ArticleTHE EXPRESSION OF APELIN AND ITS RECEPTOR APJ DURING DIFFERENT PHYSIOLOGICAL...
Recent studies implicate that apelin and its receptor APJ may have important role for the modulation of angiogenesis. The aim of this study was to further characterise the regulation of apelin/APJ...
View ArticleCharacterization of the complete mitochondrial genome of the giant silkworm...
The complete mitochondrial genome (mitogenome) of Eriogyna pyretorum (Lepidoptera: Saturniidae) was determined as being composed of 15,327 base pairs (bp), including 13 protein-coding genes (PCGs), 2...
View ArticleTargeting Promyelocytic Leukemia Protein: A Means to Regulating PML Nuclear...
The promyelocytic leukemia protein (PML) is involved in many cellular processes including cell cycle progression, DNA damage response, transcriptional regulation, viral infection, and apoptosis. These...
View ArticleChemoprevention of rat liver toxicity and carcinogenesis by Spirulina
Spirulina platensis (SP) is a filamentous cyanobacterium microalgae with potent dietary phyto-antioxidant, anti-inflammatory and anti-cancerous properties. The present study aimed to investigate the...
View ArticleBMP13 Prevents the Effects of Annular Injury in an Ovine Model
Chronic back pain is a global health problem affecting millions of people worldwide and carries significant economic and social morbidities. Intervertebral disc damage and degeneration is a major...
View ArticleAxial and appendicular skeletal transformations, ligament alterations, and...
Vertebrate Hox genes regulate many aspects of embryonic body plan development and patterning. In particular, Hox genes have been shown to regulate regional patterning of the axial and appendicular...
View ArticleIn vivo measurement of protein functional changes
Conformational changes in proteins are fundamental to all biological functions. In protein science, the concept of protein flexibility is widely used to describe protein dynamics and thermodynamic...
View ArticleHCV Antibody Response and Genotype Distribution in Different Areas and Races...
Hepatitis C virus (HCV) heterogeneity accounts for the failure of effective vaccine development and the lack of successful anti-viral therapy in some patients. Little is known about the immune...
View ArticleNuclear Localization of p38 MAPK in Response to DNA Damage
p38 MAP kinase (MAPK) is activated in response to environmental stress, cytokines and DNA damage, and mediates death, cell differentiation and cell cycle checkpoints. The intracellular localization of...
View ArticleHow Subchronic and Chronic Health Effects can be Neglected for GMOs,...
Chronic health effects are increasing in the world such as cancers, hormonal, reproductive, nervous, or immune diseases, even in young people. During regulatory toxicological subchronic tests to...
View ArticleEssential Roles of mTOR/Akt Pathway in Aurora-A Cell Transformation
We have recently demonstrated that Aurora-A kinase is a potential oncogene to develop mammary gland tumors in mice, when expressed under MMTV promoter. These tumors contain phosphorylated forms of Akt...
View ArticleConstruction of a full-length cDNA Library from Chinese oak silkworm pupa and...
In this study we successfully constructed a full-length cDNA library from Chinese oak silkworm, Antheraea pernyi, the most well-known wild silkworm used for silk production and insect food. Total RNA...
View ArticleSite-Dependent Differences in Clinical, Pathohistological, and Molecular...
The purpose was to develop a metastatic score specific to the hepatic and peritoneal site in colorectal cancer patients from clinical, pathohistological and molecular markers potentially reflecting...
View ArticleHistopathological effects of cisplatin, doxorubicin and 5-flurouracil (5-FU)...
Cisplatin, doxorubicin and fluorouracil (5-FU), drugs belonging to different chemical classes, have been extensively used for chemotherapy of various cancers. Despite extensive investigations into...
View ArticleLipoproteins, cholesterol homeostasis and cardiac health
Cholesterol is an essential substance involved in many functions, such as maintaining cell membranes, manufacturing vitamin D on surface of the skin, producing hormones, and possibly helping cell...
View ArticleAn apoA-I mimetic peptide increases LCAT activity in mice through increasing...
Lecithin cholesterol acyltransferase (LCAT) plays a key role in the reverse cholesterol transport (RCT) process by converting cholesterol to cholesteryl ester to form mature HDL particles, which in...
View ArticleThe prospects of cellulase-producing bacteria for the bioconversion of...
Lignocellulosic biomass is a renewable and abundant resource with great potential for bioconversion to value-added bioproducts. However, the biorefining process remains economically unfeasible due to...
View ArticleGene expression profiling of chromophobe renal cell carcinomas and renal...
Due to overlapping morphology, malignant chromophobe renal cell carcinomas (RCC) and benign renal oncocytomas (RO) may pose a diagnostic problem. In the present study, we have applied different...
View ArticleDiscovery of novel genetic networks associated with 19 economically important...
Quantitative or complex traits are determined by the combined effects of many loci, and are affected by genetic networks or molecular pathways. In the present study, we genotyped a total of 138...
View ArticleA novel peptide inhibits the influenza virus replication by preventing the...
Avian influenza viruses (AIV), the causative agent of avian flu or bird flu, cause widespread morbidity and mortality in poultry. The symptoms of the disease range from mild flu like symptoms to...
View ArticleProtective Effects of Garlic and Silymarin on NDEA-Induced Rats Hepatotoxicity
Background — The present study was conducted to investigate the chemopreventive effects of garlic extract and silymarin on N-nitrosodiethylamine (NDEA) and carbon tetrachloride (CCl4)-induced...
View ArticleComparative characterization of a temperature responsive gene (lactate...
The characterization of candidate loci is a critical step in obtaining insight into adaptation and acclimation of organisms. In this study of two non-model tropical (to sub-tropical) congeneric...
View ArticleDisruption of the BMEI0066 gene attenuates the virulence of Brucella...
Brucella melitensis is a facultative intracellular pathogen. An operon composed of BMEI0066, which encodes a two-component response regulator CenR, and BMEI0067, which encodes a cAMP-dependent protein...
View ArticleFungal Bioconversion of Lignocellulosic Residues; Opportunities & Perspectives
The development of alternative energy technology is critically important because of the rising prices of crude oil, security issues regarding the oil supply, and environmental issues such as global...
View ArticleBioinformatics Analysis the Complete Sequences of Cytochrome b of Takydromus...
Cytochrome b (cyt b) gene complete sequences (1143bp) of Takydromus sylvaticus were sequenced. In order to clarify the phylogenetic position of the Takydromus sylvaticus, we investigated the phylogeny...
View ArticleFailure to detect active virus replication in mast cells at various tissue...
A recent report postulated that the mast cell population is a significant reservoir for persistent HIV infection. Our study attempted to validate this hypothesis by quantitatively comparing the...
View ArticleNucleotide excision repair and recombination are engaged in repair of...
One of the major products of lipid peroxidation is trans-4-hydroxy-2-nonenal (HNE). HNE forms highly mutagenic and genotoxic adducts to all DNA bases. Using M13 phage lacZ system, we studied the...
View ArticleKrüppel-like family of transcription factors: an emerging new frontier in fat...
In mammals, adipose tissue stores energy in the form of fat. The ability to regulate fat storage is essential for the growth, development and reproduction of most animals, thus any abnormalities...
View ArticleAn apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to...
Apolipoprotein A-I (apoA-I) mimetic peptides have been pursued as new therapeutic agents for the treatment of atherosclerosis, yet their precise mechanism responsible for atheroprotection remains...
View ArticleClinical diagnosis for discogenic low back pain
Discogenic lower back pain (DLBP) is the most common type of chronic lower back pain (LBP), accounting for 39% of cases, compared to 30% of cases due to disc herniation, and even lower prevalence...
View ArticleKaryology of eight species of bats (Mammalia: Chiroptera) from Hainan Island,...
Karyotypes and chromosomal data are presented for eight bat species representing two families (Rhinolophidae and Vespertilionidae) from Hainan Island, China. The species investigated were Rhinolophus...
View ArticleAzithromycin suppresses interleukin-12p40 expression in lipopolysaccharide...
Azithromycin (AZM), a 15-member macrolide antibiotic, possesses anti-inflammatory activity. Macrophages are important in innate and acquired immunity, and produce pro-inflammatory cytokines such as...
View ArticleProteome Changes in Thai Indigenous Chicken Muscle during Growth Period
Proteomic profiling of the pectoralis muscle of Thai indigenous chickens during growth period was analyzed using two-dimensional gel electrophoresis (2-DE) and matrix assisted laser desorption...
View ArticleRole of Ldb1 in Adult Intestinal Homeostasis
Ldb1 is an essential co-regulator of transcription in embryonic development. It acts in conjunction with nuclear LIM-homeodomain and LIM-only proteins to control key events of organogenesis as...
View ArticleThe presence of alpha-catenin in the VE-cadherin complex is required for...
The majority of the leukocytes cross the endothelial lining of the vessels through cell-cell junctions. The junctional protein Vascular Endothelial (VE)-cadherin is transiently re-distributed from...
View ArticleA Comparison of the Effects of Three GM Corn Varieties on Mammalian Health
We present for the first time a comparative analysis of blood and organ system data from trials with rats fed three main commercialized genetically modified (GM) maize (NK 603, MON 810, MON 863),...
View ArticleIdentification of Anoectochilus based on rDNA ITS sequences alignment and...
The internal transcribed spacer (ITS) sequences alignment and proteomic difference of Anoectochilus interspecies have been studied by means of ITS molecular identification and surface enhanced laser...
View ArticleCloning, Expression and Purification of an Acetoacetyl CoA Thiolase from...
Thiolase I and II coexist as part of the glyoxysomal β-oxidation system in sunflower (Helianthus annuus L.) cotyledons, the only system shown to have both forms. The importance of thiolases can be...
View ArticleA receptor and binding protein interplay in the detection of a distinct...
Male moths respond to conspecific female-released pheromones with remarkable sensitivity and specificity, due to highly specialized chemosensory neurons in their antennae. In Antheraea silkmoths,...
View ArticlePhysiological and Oncogenic Aurora-A Pathway
Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently...
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