Is sodium current present in human sinoatrial node cells?
Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (INa) plays...
View ArticleIdentifications of SUMO-1 cDNA and Its Expression Patterns in Pacific White...
Small ubiquitin-like modifiers (SUMO) work in a similar way as ubiquitin to alter the biological properties of a target protein by conjugation. A shrimp SUMO cDNA named LvSUMO-1 was identified in...
View ArticleDiverse protein regulations on PHA formation in Ralstonia eutropha on short...
Organic acids are considered as potential substrates for biosynthesis of polyhydroxyalkaonates. The acids may also be the metabolic inhibitors at moderate concentration levels. In this study,...
View ArticleA Curriculum Vitae of Teeth: Evolution, Generation, Regeneration
The ancestor of recent vertebrate teeth was a tooth-like structure on the outer body surface of jawless fishes. Over the course of 500,000,000 years of evolution, many of those structures migrated...
View ArticleBirth weight and coronary artery disease. The effect of gender and diabetes
Background: The developmental origin theory of coronary heart disease proposes that undernutrition in utero permanently changes body functions and metabolism leading to an increased risk of coronary...
View ArticleIn vivo evidence of hepato- and reno-protective effect of garlic oil against...
Sodium nitrite (NaNO2), a food color fixative and preservative, contributes to carcinogenesis. We investigated the protective role of garlic oil against NaNO2-induced abnormalities in metabolic...
View ArticleThe Role of SRC-1 in Murine Prostate Carcinogenesis Is Nonessential due to a...
The androgen and androgen receptor (AR)-regulated gene expression plays important roles in normal prostate and prostate cancer development, and AR transcriptional control of genes is mediated by...
View ArticleOsteoarthitis of Leptin-Deficient ob/ob Mice in Response to Biomechanical...
Objective: Mechanotransduction is the mechanism that due to reacting chondrocytes on biomechanical loading of body mass. Higher biomechanical loading lead to increased degeneration of chondrocytes,...
View ArticleCorrelated alterations in prostate basal cell layer and basement membrane
Our recent studies revealed that focal basal cell layer disruption (FBCLD) induced auto-immunoreactions represented a contributing factor for human prostate tumor progression and invasion. As the...
View ArticleResponses of Plasma Acetate Metabolism to Hop (Humulus lupulus L.) in Sheep
An isotope dilution method using [1-13C]sodium (Na) acetate was conducted to determine the effect of feeding hop (Humulus lupulus L.) residues on plasma acetate metabolism in six adult crossbred...
View ArticleCharacterization of persistent TTX-R Na+ currents in physiological...
Persistent tetrodotoxin-resistant (TTX-R) Na+ (Nav1.9/SCN11A) currents are not normally recorded in vagal afferent neurons (VANs) with 50 mM of extracellular Na+ although the functional expression of...
View ArticleOld can be new again: HAPPY whole genome sequencing, mapping and assembly
During the last three decades, both genome mapping and sequencing methods have advanced significantly to provide a foundation for scientists to understand genome structures and functions in many...
View ArticleVesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by...
We investigated the potential usefulness of vesnarinone, a novel cytokine inhibitor, for the treatment of lung fibrosis using a murine model of bleomycin (BLM)-induced pulmonary fibrosis. Mice were...
View ArticleBody fat mass reduction and up-regulation of uncoupling protein by novel...
We have found natural products exhibiting lipolysis-promoting activity in subcutaneous adipocytes, which are less sensitive to hormones than visceral adipocytes. The activities and a action mechanisms...
View ArticleA male-specific odorant receptor conserved through the evolution of sex...
In many moths, mate-finding communication is mediated by the female sex pheromones. Since differentiation of sex pheromones is often associated with speciation, it is intriguing to know how the...
View ArticleIdentification of candidate genes for congenital splay leg in piglets by...
The congenital splay leg syndrome in piglets is characterized by a temporarily impaired functionality of the hind leg muscles immediately after birth. Etiology and pathogenetic mechanisms for the...
View ArticleModulation of NKT cells and Th1/Th2 imbalance after α-GalCer treatment in...
Purpose: The purpose of this study was to determine whether α-galactosylceramide (α-GalCer), a synthetic glycolipid agonist of natural killer T (NKT) cells, can ameliorate exercise-induced immune...
View ArticleTHE EXPRESSION OF APELIN AND ITS RECEPTOR APJ DURING DIFFERENT PHYSIOLOGICAL...
Recent studies implicate that apelin and its receptor APJ may have important role for the modulation of angiogenesis. The aim of this study was to further characterise the regulation of apelin/APJ...
View ArticleCharacterization of the complete mitochondrial genome of the giant silkworm...
The complete mitochondrial genome (mitogenome) of Eriogyna pyretorum (Lepidoptera: Saturniidae) was determined as being composed of 15,327 base pairs (bp), including 13 protein-coding genes (PCGs), 2...
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