Targeting Promyelocytic Leukemia Protein: A Means to Regulating PML Nuclear...
The promyelocytic leukemia protein (PML) is involved in many cellular processes including cell cycle progression, DNA damage response, transcriptional regulation, viral infection, and apoptosis. These...
View ArticleChemoprevention of rat liver toxicity and carcinogenesis by Spirulina
Spirulina platensis (SP) is a filamentous cyanobacterium microalgae with potent dietary phyto-antioxidant, anti-inflammatory and anti-cancerous properties. The present study aimed to investigate the...
View ArticleBMP13 Prevents the Effects of Annular Injury in an Ovine Model
Chronic back pain is a global health problem affecting millions of people worldwide and carries significant economic and social morbidities. Intervertebral disc damage and degeneration is a major...
View ArticleAxial and appendicular skeletal transformations, ligament alterations, and...
Vertebrate Hox genes regulate many aspects of embryonic body plan development and patterning. In particular, Hox genes have been shown to regulate regional patterning of the axial and appendicular...
View ArticleIn vivo measurement of protein functional changes
Conformational changes in proteins are fundamental to all biological functions. In protein science, the concept of protein flexibility is widely used to describe protein dynamics and thermodynamic...
View ArticleHCV Antibody Response and Genotype Distribution in Different Areas and Races...
Hepatitis C virus (HCV) heterogeneity accounts for the failure of effective vaccine development and the lack of successful anti-viral therapy in some patients. Little is known about the immune...
View ArticleNuclear Localization of p38 MAPK in Response to DNA Damage
p38 MAP kinase (MAPK) is activated in response to environmental stress, cytokines and DNA damage, and mediates death, cell differentiation and cell cycle checkpoints. The intracellular localization of...
View ArticleHow Subchronic and Chronic Health Effects can be Neglected for GMOs,...
Chronic health effects are increasing in the world such as cancers, hormonal, reproductive, nervous, or immune diseases, even in young people. During regulatory toxicological subchronic tests to...
View ArticleEssential Roles of mTOR/Akt Pathway in Aurora-A Cell Transformation
We have recently demonstrated that Aurora-A kinase is a potential oncogene to develop mammary gland tumors in mice, when expressed under MMTV promoter. These tumors contain phosphorylated forms of Akt...
View ArticleConstruction of a full-length cDNA Library from Chinese oak silkworm pupa and...
In this study we successfully constructed a full-length cDNA library from Chinese oak silkworm, Antheraea pernyi, the most well-known wild silkworm used for silk production and insect food. Total RNA...
View ArticleSite-Dependent Differences in Clinical, Pathohistological, and Molecular...
The purpose was to develop a metastatic score specific to the hepatic and peritoneal site in colorectal cancer patients from clinical, pathohistological and molecular markers potentially reflecting...
View ArticleHistopathological effects of cisplatin, doxorubicin and 5-flurouracil (5-FU)...
Cisplatin, doxorubicin and fluorouracil (5-FU), drugs belonging to different chemical classes, have been extensively used for chemotherapy of various cancers. Despite extensive investigations into...
View ArticleLipoproteins, cholesterol homeostasis and cardiac health
Cholesterol is an essential substance involved in many functions, such as maintaining cell membranes, manufacturing vitamin D on surface of the skin, producing hormones, and possibly helping cell...
View ArticleAn apoA-I mimetic peptide increases LCAT activity in mice through increasing...
Lecithin cholesterol acyltransferase (LCAT) plays a key role in the reverse cholesterol transport (RCT) process by converting cholesterol to cholesteryl ester to form mature HDL particles, which in...
View ArticleThe prospects of cellulase-producing bacteria for the bioconversion of...
Lignocellulosic biomass is a renewable and abundant resource with great potential for bioconversion to value-added bioproducts. However, the biorefining process remains economically unfeasible due to...
View ArticleGene expression profiling of chromophobe renal cell carcinomas and renal...
Due to overlapping morphology, malignant chromophobe renal cell carcinomas (RCC) and benign renal oncocytomas (RO) may pose a diagnostic problem. In the present study, we have applied different...
View ArticleDiscovery of novel genetic networks associated with 19 economically important...
Quantitative or complex traits are determined by the combined effects of many loci, and are affected by genetic networks or molecular pathways. In the present study, we genotyped a total of 138...
View ArticleA novel peptide inhibits the influenza virus replication by preventing the...
Avian influenza viruses (AIV), the causative agent of avian flu or bird flu, cause widespread morbidity and mortality in poultry. The symptoms of the disease range from mild flu like symptoms to...
View ArticleProtective Effects of Garlic and Silymarin on NDEA-Induced Rats Hepatotoxicity
Background — The present study was conducted to investigate the chemopreventive effects of garlic extract and silymarin on N-nitrosodiethylamine (NDEA) and carbon tetrachloride (CCl4)-induced...
View ArticleComparative characterization of a temperature responsive gene (lactate...
The characterization of candidate loci is a critical step in obtaining insight into adaptation and acclimation of organisms. In this study of two non-model tropical (to sub-tropical) congeneric...
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